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Manufacturer supply high quality Ethyl propionylacetate 4949-44-4 with ISO standards
- Molecular Formula: C7H12O3
- Molecular Weight: 144.17
- Appearance/Colour: colourless liquid
- Vapor Pressure: 0.475mmHg at 25°C
- Refractive Index: n20/D 1.422(lit.)
- Boiling Point: 192.988 °C at 760 mmHg
- PKA: 10.58±0.46(Predicted)
- Flash Point: 77.778 °C
- PSA： 43.37000
- Density: 0.996 g/cm3
- LogP: 0.91870
Ethyl propionylacetate(Cas 4949-44-4) Usage
|
General Description |
Ethyl propionylacetate reacts with tropolone p-toluenesulfonate in the presence of sodium ethoxide to give 3-propionyl-2H-cyclohepta[b]furan-2-one. |
InChI:InChI=1/C7H12O3/c1-3-6(8)5-7(9)10-4-2/h3-5H2,1-2H3
4949-44-4 Relevant articles
Enones with Strained Double Bonds. 5. The 2-Methylbicyclonon-1-en-3-one System
House, Herbert O.,DeTar, Marvin B.,Sieloff, Ronald F.,VanDerveer, Don
, p. 3545 - 3549 (1980)
Reaction of the bromo ketone 8 with Et3N...
Screening, synthesis, crystal structure, and molecular basis of 6-amino-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles as novel AKR1C3 inhibitors
Zheng, Xuehua,Jiang, Zan,Li, Xiaolin,Zhang, Chen,Li, Zhe,Wu, Yinuo,Wang, Xinhua,Zhang, Chao,Luo, Hai-bin,Xu, Jun,Wu, Deyan
supporting information, p. 5934 - 5943 (2018/11/23)
AKR1C3 is a promising therapeutic target...
PROCESS FOR ACYL-TRANSFER ENZYME REACTIONS WITH ACYL- COENZYME A
-
Paragraph 0095, (2016/07/27)
The present invention relates to a metho...
General, Simple, and Chemoselective Catalysts for the Isomerization of Allylic Alcohols: The Importance of the Halide Ligand
Erbing, Elis,Vázquez-Romero, Ana,Bermejo Gómez, Antonio,Platero-Prats, Ana E.,Carson, Fabian,Zou, Xiaodong,Tolstoy, P?ivi,Martín-Matute, Belén
supporting information, p. 15659 - 15663 (2016/10/25)
Remarkably simple IrIIIcatalysts enable ...
Chemoenzymatic asymmetric synthesis of pregabalin precursors via asymmetric bioreduction of β-cyanoacrylate esters using ene-reductases
Winkler, Christoph K.,Clay, Dorina,Davies, Simon,O'Neill, Pat,McDaid, Paul,Debarge, Sebastien,Steflik, Jeremy,Karmilowicz, Mike,Wong, John W.,Faber, Kurt
, p. 1525 - 1533 (2013/04/10)
The asymmetric bioreduction of a library...
4949-44-4 Process route
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-
141-97-9
ethyl acetoacetate
-
-
74-88-4
methyl iodide
-
-
4949-44-4
ethyl propanoylacetate
Conditions
| Conditions | Yield |
|---|---|
|
With
n-butyllithium; sodium hydride;
In
tetrahydrofuran; hexane;
at 25 ℃;
for 0.5h;
|
85%
|
|
With
n-butyllithium; sodium hydride;
Yield given. Multistep reaction;
1) THF, 0 deg C, 20 min, 2) THF, room temperature, 30 min;
|
|
|
ethyl acetoacetate;
With
n-butyllithium;
In
tetrahydrofuran;
at 0 - 10 ℃;
for 0.166667h;
methyl iodide;
In
tetrahydrofuran;
at 10 - 20 ℃;
|
-
-
2033-24-1
cycl-isopropylidene malonate
-
-
79-03-8
propionyl chloride
-
-
4949-44-4
ethyl propanoylacetate
Conditions
| Conditions | Yield |
|---|---|
|
cycl-isopropylidene malonate; propionyl chloride;
With
pyridine;
In
dichloromethane;
at 0 - 20 ℃;
for 3h;
Inert atmosphere;
In
ethanol;
Reflux;
|
4949-44-4 Upstream products
-
64-17-5
ethanol
-
33279-01-5
3-oxo-pentanenitrile
-
39580-00-2
1,1-dichloro-pent-1-en-3-one
-
141-52-6
sodium ethanolate
4949-44-4 Downstream products
-
104439-88-5
5-ethyl-2-methyl-1-phenyl-1,2-dihydro-pyrazol-3-one
-
67244-24-0
ethyl 2-propyl-propionylacetate
-
53939-83-6
6-ethyl-2,3-dihydro-2-thioxopyrimidin-4(1H)-one
-
916319-06-7
5-ethyl-2-phenyl-1,2-dihydro-pyrazol-3-one
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